Preparation of Ear Drops

Ear drops are liquid preparations meant for instillation into the ear. In these preparations, the drug is usually dissolved or suspended in a suitable solvent such as propylene glycol, polyethylene glycol, glycerol alcohol, and water or a mixture of these. Aqueous vehicle is generally not preferred because the secretions in the ear are fatty, and as such these do not easily mix with water.

Those are generally used for their cleansing, pain-relieving, and antiseptic actions. The main classes of drugs include analgesics like benzocaine, antibiotics like neomycin and chloramphenicol, and anti-inflammatory agents such as cortisone and dexamethasone. Wax softening agents include hydrogen peroxide and sodium bicarbonate. It is usually supplied in amber-colored, glass bottles with a teat and dropper closure or plastic squeeze bottles.

Ear Drops


Chloramphenicol Ear Drops

Chloramphenicol – 5 g

Propylene glycol q.s to 100 ml

Chloramphenicol ear drops may be prepared by dissolving Chloramphenicol’s insufficient quantity of Propylene glycol and finally making up the final volume with it.

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