Aim: To prepare and submit 100 gm Tannic acid suppositories (Cocoa suppositories).
Requirements: Tannic acid, Theobroma oil, Beaker, Glass rod, Mould, etc.
Theory: A suppository is a solid dosage form that is inserted into the rectum (rectal suppository), vagina (vaginal suppository) or urethra (urethral suppository), where it dissolves or melts and exerts local or systemic effects. Suppositories are used to deliver both systemically and locally acting medications. Tannic acid suppositories are meant for Vaginal application.
Formula:
| Ingredients | Standard formula |
| Tannic acid | 0.2 gm |
| Theobroma oil | q.s. |
Procedure:
- Add lubricant to the mould and remove the excess lubricant by draining.
- Cool the lubricated mould over ice.
- Heat Theobroma oil in a porcelain dish over a water bath. Avoid overheating.
- Remove the dish from the water bath as soon as the mass is molten.
- Powder the weighed amount of tannic acid.
- Add the powdered tannic acid to the molten theobroma oil.
- Mix the tannic acid with a spatula.
- Pour the mixture into the holes in the moulds when the mixture is sufficiently thickened and flows sluggishly.
- Fill each mould properly.
- Place the mould on ice and remove excess mass carefully with a sharp knife.
- When the suppositories have completely set hard, open the mould and remove the suppositories by applying slight pressure on the broad ends.
- Remove the lubricant on the final product, if any, by rolling on the filter papers.
Category: For the local application of antimicrobial agents in the vaginal cavity.
Storage: Preserve in a well-closed container to protect from atmospheric moisture and temperature.
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