Assay of Ethosuximide

Molecular formula: C7H11NO2 

Molecular weight: 141.17 

Materials Required: Ethosuximide: 0.2 g; dimethylformamide: 50 mL; azo-violet (0.1% W/V in DMF): 2 drops; sodium methoxide 0.1 N. 

Procedure: Weigh accurately about 0.2 g of ethosuximide and dissolve in 50 mL of dimethyl formamide, add 2 drops of azo-violet solution as an indicator, and titrate with 0.1 N sodium methoxide until gives a deep blue color as an endpoint. Take precautions to prevent the absorption of atmospheric carbon dioxide. Perform a blank determination and make any necessary corrections. 


Factor Calculation: 

1 mole of CH3ONa ≅ 1 mole of ethosuximide 

1000 mL of 1N CH3ONa ≅ 141.17 g of C7H11NO2 

1 mL of 0.1N CH3ONa ≅ 0.01417 g of C7H11NO2 

Make sure you also check our other amazing Article on : Assay of Methacholine Chloride
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