Assay of Ibuprofen

Molecular formula: C13H18O2  

Molecular Weight: 206.3 

Assay: Weigh accurately about 0.4 g, dissolve in 100 mL of ethanol (95%), and titrate with 0.1 M sodium hydroxide using 0.2 mL of phenolphthalein solution as an indicator. Carry out a blank titration. 


Factor Calculation: 

1 Mole of NaOH ≅ 1 Mole of ibuprofen 

1000 mL of 1M NaOH ≅ 206.3 g of C13H18O2  

1 mL of 0.1M NaOH ≅ 0.02063 g of C13H18O2  

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