Assay of Tolbutamide

Molecular Formula: C12H18N2O3

Molecular Weight: 270.4 

Assay: Weigh accurately about 0.5 g and dissolve in a mixture of 40 mL of ethanol (95%) and 20 mL of water. Titrate with 0.1 M sodium hydroxide using phenolphthalein solution as an indicator. 


Assay of Tolbutamide

Factor Calculation: 

1 Mole of NaOH ≅ 1 Mole of Tolbutamide 

1000 mL of 1M NaOH ≅ 270.4 g of C12H18N2O3S    

1 mL of 0.1M NaOH ≅ 0.02704g of C12H18N2O3

Make sure you also check our other amazing Article on : Assay of Zinc Oxide
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