Synthesis and Medicinal Use of Purine

Synthesis and Medicinal Use of Purine: Purine is a heterocyclic aromatic compound that consists of a pyrimidine ring fused to an imidazole ring. Together with certain pyrimidine bases, purines are constituents of DNA and RNA. Purines also act as hormones and neurotransmitters and are present in some coenzymes.

Biologically important purines include.

Synthesis and Medicinal Use of Purine

It was first synthesized by German chemist Emil Fischer in 1884.

Synthesis of Purine:


Synthesis of Purine

(2) Traube Synthesis:

It begins with a 4-amino-6-hydroxy pyrimidine or 4, 5-diamino pyrimidine involving the nitrosation at 5-position, reduction of nitroso to the amino group using ammonium sulfide, and ring closure with formic acid or chloro carbonic ester.

Synthesis of Purine

Caffeine synthesis:

Synthesis of Purine

Medicinal Uses of Purine:

Purine analogs are having antibacterial, antifungal, antitumor, antiviral, and anti-HIV activity. Important drugs from the purine category include caffeine (CNS stimulant), 6-mercaptopurine (anti-cancer), azithromycin. Drugs having isostere of purine include sildenafil (erectile dysfunction), allopurinol (anti-gout), tubercidin (anti-cancer).

Medicinal Uses of Purine
Make sure you also check our other amazing Article on : Synthesis and Reactions of Acridine
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