Assay of Diclofenac Sodium

Molecular Formula: C14H10Cl2NNaO2  

Material required: Diclofenac Na: 250 mg, glacial acetic acid: 30 mL, 0.1N perchloric acid and crystal violet. 

Molecular Weight: 318.13 

Procedure: Weigh accurately 250 mg of diclofenac sodium dissolved in 30 mL of glacial acetic acid, and titrated with 0.1N perchloric acid; the endpoint is determined by using crystal violet as an indicator. The endpoint is blue to green. 


Assay of Diclofenac Sodium

Factor Calculation: 

1 Mole of HClO4 ≅ 1 Mole of diclofenac sodium 

1000 mL of 1M HClO4 ≅ 318.13 g of C14H10Cl2NNaO2  

1 mL of 0.1N HClO4 ≅ 0.03181 g of C14H10Cl2NNaO2  

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